Basics of opioid analgesic pharmacodynamics
نویسندگان
چکیده
منابع مشابه
Non-opioid analgesic poisoning.
Since the first cases of severe and fatal liver damage were reported in 1966,1,2 overdose of paracetamol has become the cause of 100–200 deaths in the UK each year.3 Paracetamol toxicity remains the leading cause of fulminant hepatic failure in the UK and is a common reason for liver transplantation.4,5 Knowledge of the toxic mechanism (Fig 1) has led to effective antidotes which provide substr...
متن کاملManagement of opioid analgesic overdose.
Copyright © 2012 Massachusetts Medical Society. Opioid analgesic overdose is a preventable and potentially lethal condition that results from prescribing practices, inadequate understanding on the patient’s part of the risks of medication misuse, errors in drug administration, and pharmaceutical abuse.1,2 Three features are key to an understanding of opioid analgesic toxicity. First, opioid ana...
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Compound trans-4-(p-bromophenyl)-4-(dimethylamino)-1-(2-thiophen-2-yl-ethyl)-cyclohexanol (C8813), structurally unrelated to morphine, is a novel analgesic. The present study examined the antinociception, opioid receptor selectivity and in vitro activity of C8813. The antinociceptive activity was evaluated using mouse hot plate and acetic acid writhing tests. In mouse hot plate test, the antino...
متن کاملAdverse effects of opioid analgesic drugs.
Opioids were available in clinical practice since before the birth of modern anaesthesia--Setürner isolated morphine in 1806. They have a record of safety which is reflected in their high therapeutic ratios, especially the synthetic opioids introduced recently (table III). The most serious immediate adverse effect, respiratory depression, is a predictable effect related closely to analgesia. It...
متن کاملShould opioid abusers be discharged from opioid-analgesic therapy?
Editor’s Note: This editorial by Dr. Peggy Compton, and the three papers in this issue by Drs. Webster, Fishbain, Zacny, and their colleagues, initiate the Opioids, Substance Abuse & Addiction Section of Pain Medicine. Under the leadership of section co-editors Steve Passik, PhD, and Lynn Webster, MD, PhD, and their distinguished colleagues, this section will inform our readership about this cr...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 1986
ISSN: 0885-3924
DOI: 10.1016/s0885-3924(86)80009-4